For your parents' friends
Consider Walden Inn, set on 32 of acres of idyllic farmland and located in Aurora, a great place for your guests to relax and unwind for the weekend. If they'd rather not leave the comfort of their equestrian suite, there's an air bath tub and an in-room fireplace. Suites with cedar-paneled ceilings have views of the countryside and gardens, as well as large walk-in showers (with plenty of room for two -- wink, wink) so guests will feel like they're on a second honeymoon. Walden Inn, Aurora, (330) 562-5508
For long-distance relatives
Family members coming in from out of town are likely to make a vacation out of the trip, so send them to The Renaissance Hotel, where they can soak up some Cleveland flavor. If they ever leave their posh rooms -- which feature sleek décor, marble bathrooms and 42-inch flat-screens -- guests can explore the hopping downtown area, including the Rock and Roll Hall of Fame, Progressive Field and Tower City. The Renaissance Hotel, Cleveland, (216) 696-5600
For guests with tykes in tow
Families will love Hilton Netherland Plaza in Cincinnati, located in the heart of downtown near Tower Place Mall. The hotel has an indoor pool (bring on the floaties!), and there's a room-service menu just for kids. Bonus: They have onsite babysitting services so the kids can stay back while Mom and Dad hang at your reception. Hilton Netherland Plaza, Cincinnati, (513) 421-9100
For your friends
Recommend the The Lofts in Columbus. This small boutique hotel is located in the center of Columbus near all the downtown bars and restaurants -- perfect for an old college crew looking for a late-night hangout. The hotel also has a private workout room, Frette terry robes and rooms with floor-to-ceiling windows! The Lofts, Columbus, (800) 735-6387
Special thanks to Gina Jokilehto-Schigel of Shi Shi Events in Cleveland